Norihiro Tokitoh is a professor of chemistry at the Institute for Chemical Research (ICR), Kyoto University. He received his Ph. D. (1985) from the University of Tokyo. After spending some years as Research Associate (1986) and then Assistant Professor (1987) of Tsukuba Univ., and Assistant Professor (1989) and then Associate Professor (1994) of The University of Tokyo, he was appointed as Professor of the Institute for Fundamental Organic Chemistry, Kyushu Univ. in 1998 and moved to ICR, Kyoto University in 2000. He served as Guest Professor at Institute for Molecular Science (2001-2003), Technische Universität Braunschweig (2004-2007), and Universität Bonn (2013-), and Director of ICR (2008-2012, 2014-).

His main research interest is focused on novel bonding and structures in heavier main group element chemistry. He received Incentive Award in Synthetic Organic Chemistry, Japan (1992), Progress Award in Silicon Chemistry, Japan (1996), Japan IBM Science Award (1998), Chemical Society of Japan Award for Creative Work (2003), Alexander von Humboldt Research Award (2003), Lectureship Award of National Science Council, Republic of China (2007), Kim Yong Hae Lectureship Award of KAIST, Korea (2010), BCSJ Awards (2002, 2005, 2007, 2009, 2010, and 2013), Best Reviewer Commendation (JSPS; 2010), and Re-invitation by AvH Research Award (2013). He contributed to several chemistry journals, such as Journal of Physical Organic Chemistry (Associate Editor for Asia, 1998-2006), Organometallics (Advisory Board Member, 2006-2009), Journal of Sulfur Chemistry (Editorial Board Member, 2001-), Main Group Metal Chemistry (Editorial Board Member, 2011-) and Bulletin of the Chemical Society of Japan (Editor-in-chief, 2013-).

Synthesis and Characterization of a Stable Dibismuthene: Evidence for a Bi-Bi Double Bond, Tokitoh, N.; Arai, Y.; Okazaki, R.; Nagase, S. Science, 1997, 277, 78-80.

A Stable Neutral Silaaromatic Compound, 2-{2,4,6-Tris[bis(trimethylsilyl)methyl]-phenyl}-2-silanaphthalene, Tokitoh, N.; Wakita, K.; Okazaki, R.; Nagase, S.; Schleyer, P. v. R.; Jiao, H. J. J. Am. Chem. Soc. 1997, 119, 6951-6952.

New Progress in the Chemistry of Stable Metallaaromatic Compounds of Heavier Group 14 Elements, Tokitoh, N. Acc. Chem. Res. 2004, 37, 86-94.

Synthesis and Reactions of a Stable 1,2-Diaryl-1,2-dibromodisilene: A Precursor for Substituted Disilenes and a 1,2-Diaryldisilyne, Sasamori, T.; Hironaka, K. ; Sugiyama, Y.; Takagi, N.; Nagase, S.; Hosoi, Y. ; Furukawa, Y.; Tokitoh, N. J. Am. Chem. Soc. 2008, 130, 13856-13857.

Stable Heavier Carbene Analogues, Mizuhata, Y.; Sasamori, T.; Tokitoh, N. Chem. Rev. 2009, 109, 3479-351.

Noda, et al, “Trapping and emission of photons by a single defect in a photonic bandgap structure”, Nature, vol. 407, No. 6804, pp.608-610 (OCT 5 2000)

Noda, et al, “Full three-dimensional photonic bandgap crystals at near-infrared wavelengths”, Science, vol.289 No. 5479, pp. 604-606 (JUL 28 2000)

Imada, Noda, et al, “Coherent two-dimensional lasing action in surface-emitting laser with triangular-lattice photonic crystal structure”, Appl. Phys. Lett., vol.75, No.3, pp. 316-318 (JUL 19 1999).

Akahane, Noda, et al, “High-Q photonic nanocavity in a two-dimensional photonic crystal”, Nature, vol. 425, No. 6961, pp. 944-947 (OCT 30 2003).

Hirose, Noda, et al, “Watt-class high-power, high-beam-quality photonic-crystal lasers”, Nature Photonics, vol.8, No.5, pp. 406-411(May 2014).

and over 410 other publications
Total citation: over 13,500

Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, & Hagiwara M, (2015) Selective inhibition of the kinase DYRK1A by targeting its folding process. Nature Communications. 7:11391. dol: 10.1038.

Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito I, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M. (2015) Na,K-ATPaseα3 Is a Death Target of Alzheimer Patient Amyloid-β Assembly. Proc Natl Acad Sci USA. 112(32):4465-4474.

Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takauchi A, Hosoya T, Suzuki T, and Hagiwara M, (2015) Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc Natl Acad Sci USA. 112(9):2764-2769.

Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y. (2014) RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing. Nat. Struct. Mol. Biol. 21(9):778-786.

Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, and Hagiwara M. (2014) CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. J Clin Invest. 124(8):3479–3488.

Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M,　Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P. (2013)　Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J Clin Invest. 123(6):2475-2487.

Kuroyanagi H, Watanabe Y, and Hagiwara M. (2013)　CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet. 9(2):e1003337

Amin EM, Hua J, Cheung MK, Ni L, Kase S, Ren-nel ES, Gammons M, Nowak DG, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton D, Bates DO, Ladomery MR (2011) WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell 20(6):768-780.

Ninomiya K, Kataoka N, and Hagiwara M. (2011) Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor. J Cell Biol. 195(1):27-40.

Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M (2011) Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nature Commun 2, 308.

Education:
B.Sc. (Mathematics), 1983, Kyoto University
M. Sc. Med. (Genetics), 1986, Osaka University Graduate School of Medicine
Ph.D. (Molecular Biology), 1990, Kyoto University Graduate School of Medicine

Research Interests:

Human Disease Genomics
Integrated omics analysis of human multigenetic disorders
Large-scale genome cohort study

Professor Fumihiko Matsuda obtained his Ph.D. from Kyoto University Graduate School of Medicine in 1990 under the supervision of Professor Tasuku Honjo. He was appointed as an assistant professor at Kyoto University Graduate School of Medicine in July 1990. His work throughout the period at Kyoto University until July 1998 is the elucidation of the organization of the human immunoglobulin heavy chain variable region (VH) gene locus. In 1998, he completed the nucleotide sequence of the entire locus and succeeded in the elucidation of genetic basis of antibody diversity. This project is a highly and globally recognized example of a successful genetic analysis of multigene family, and his work is in many textbooks of immunology.

In 1998, he joined Centre National de Genotypage in Evry, France as the head of gene identification. In 2003, he obtained a double appointment as a Professor of Kyoto University Graduate School of Medicine. From 2007 to 2010, he served as the directeur de recherche of INSERM (U. 852) and since 2008 he has been the Director of the Center for Genomic Medicine. Through various positions he has engaged, he has consistently devoted himself to the research for the human disease genomics using genome-wide approach.

His major research interests include integrated omics analysis of human multigenetic disorders and large-scale genome cohort study. He has experience in working in France for 10 years with international collaborators and is also promoting international collaborations with France, Canada, U.K. and Asian countries. By these reasons, nearly 50% of his publications are from international collaborations.

‘Young Investigator Award’　September 2000, by The Japanese Biochemical Society
‘Award of Japanese Society for Immunology’　November 2000, by Japanese Society for Immunology

Matsuda, F., Shin, E. K., Nagaoka, H., Matsumura, R., Haino, M., Fukita, Y., Taka-ishi, S., Imai, T., Riley, J. H., Anand, R., Soeda, E. and Honjo, T. (1993) Structure and physical map of 64 variable segments in the 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nature genetics. 3, 88-94

Matsuda, F., Ishii, K., Bouvagnet, P., Kuma, K., Hayashida, H., Miyata, T. and Honjo, T. (1998) The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J. Exp. Med. 188, 2151-2162

International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431, 931-945.

Vasilescu, A., Terashima, Y., Enomoto, M., Heath, S., Poonpiriya, V., Gatanaga, H., Do, H., Diop, G., Hirtzig, T., Auewarakul, P., Lauhakirti, D., Sura, T., Charneau, P., Marullo, S., Therwath, A., Oka, S., Kanegasaki, S., Lathrop, M., Matsushima, K., Zagury, J. -F. and Matsuda, F. (2007) A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients. Proc. Natl. Acad. Sci. U. S. A. 104, 3354-3359.

Hung, R.J., McKay, J.D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Chen, C., Goodman, G., Field, J.K., Liloglou, T., Xinarianos, G., Cassidy, A., McLaughlin, J., Liu, G., Narod, S., Krokan, H.E., Skorpen, F., Elvestad, M.B., Hveem, K., Vatten, L., Linseisen, J., Clavel-Chapelon, F., Vineism P., Bueno-de-Mesquita, H.B., Lund, E., Martinez, C., Bingham, S., Rasmuson, T., Hainaut, P., Riboli, E., Ahrens, W., Benhamou, S., Lagiou, P., Trichopoulos, D., Holcátová, I., Merletti, F., Kjaerheim, K., Agudo, A., Macfarlane, G., Talamini, R., Simonato, L., Lowry, R., Conway, D.I., Znaor, A., Healy, C., Zelenika, D., Boland, A., Delepine, M., Foglio, M., Lechner, D., Matsuda, F., Blanche, H., Gut, I., Heath, S., Lathrop, M. and Brennan, P. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 452, 633-637.

SEARCH Collaborative Group, Link, E., Parish, S., Armitage, J., Bowman, L., Heath, S., Matsuda, F., Gut, I., Lathrop, M. and Collins, R. (2008) SLCO1B1 variants and statin-induced myopathy–a genomewide study. N. Engl. J. Med. 359, 789-799.

Takahashi, M., Saenko, V. A., Rogounovitch T. I., Kawaguchi, T., Drozd, V. M., Takigawa-Imamura, H., Natallia M. Akulevich, N. M., Ratanajaraya, C., Mitsutake, N., Takamura, N., Danilova, L. I., Lushchik, M. L., Demidchik, Y. E., Heath, S., Yamada, R., Lathrop, M., Matsuda, F. and Yamashita, S. (2010) The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. Hum. Mol. Genet. 19, 2516-2523.

Okada, Y., Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., Suzuki, A., Yoshida, S., Graham, R. R., Manoharan, A., Ortmann, W., Bhangale, T., Denny, J. C., Carroll, R. J., Eyler, A. E., Greenberg, J. D., Kremer, J. M., Pappas, D. A., Jiang, L., Yin, J., Ye, L., Su, D. F., Yang, J., Xie, G., Keystone, E., Westra, H. J., Esko, T., Metspalu, A., Zhou, X., Gupta, N., Mirel, D., Stahl, E. A., Diogo, D., Cui, J., Liao, K., Guo, M. H., Myouzen, K., Kawaguchi, T., Coenen, M. J. H., van Riel, P. L. C. M., van de Laar, M. A. F. J., Guchelaar, H. J., Huizinga, T. W. J., Dieude, P., Mariette, X., Bridges Jr, S. L., Zhernakova, A., Toes, R. E. M., Tak, P. P., Miceli-Richard, C., Bang, S. Y., Lee, H. S., Martin, J., Gonzalez-Gay, M. A., Rodriguez-RodriguezL., Rantapaa-Dahlqvist, S., Arlestig, L., Choi, H. K., Kamatani, Y., Galan, P., Lathrop, M., the RACI consortium, the GARNET consortium, Eyre, S., Bowes, J., Barton, A., de Vries, N., Moreland, L. W., Criswell, L. A., Karlson, E. W., Taniguchi, A., Yamada, R., Kubo, M., Liu, J. S., Bae, S. C., Worthington, J., Padyukov, L., Klareskog, L., Gregersen, P. K., Raychaudhuri, S., Stranger, B. E., De Jager, P. L., Franke, L., Visscher, P. M., Brown, M. A., Yamanaka, H., Mimori, T., Takahashi, A., Xu, H., Behrens, T. W., Siminovitch, K. A., Momohara, S., Matsuda, F., Yamamoto, K. and Plenge, R. M. (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376-381.

Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T. R., Matsuda, F. and Nagata, S. (2014) Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 344, 1164-1168.

Higasa, K., Miyake, N., Yoshimura, J., Okamura, K., Niihori, T., Saitsu, H., Doi, K., Shimizu, M., Nakabayashi, K., Aoki, Y., Tsurusaki, Y., Morishita, S., Kawaguchi, T., Migita, O., Nakayama, K., Nakashima, M., Mitsui, J., Narahara, M., Hayashi, K., Funayama, R., Yamaguchi, D., Ishiura, H., Ko, W. Y., Hata, K., Nagashima, T., Yamada, R., Matsubara, Y., Umezawa, A., Tsuji, S., Matsumoto, N. and Matsuda, F. (2016) Human Genetic Variation Database (HGVD), a reference database of genetic variations in the Japanese population. J. Hum. Genet. Feb 25. doi: 10.1038/jhg.2016.12. [Epub ahead of print]

■ Papers

Inequality of Bogomolov-Gieseker type on arithmetic surfaces. Duke Math. J. 74 (1994), no. 3, 713-761.

Arithmetic Bogomolov-Gieseker’s inequality. Amer. J. Math. 117 (1995), no. 5, 1325-1347.

Relative Bogomolov’s inequality and the cone of positive divisors on the moduli space of stable curves. J. Amer. Math. Soc. 11 (1998), no. 3, 569-600.

The continuity of Deligne’s pairing. Internat. Math. Res. Notices 1999, no. 19, 1057-1066.

Arithmetic height functions over finitely generated fields. Invent. Math. 140 (2000), no. 1, 101-142.

A generalization of conjectures of Bogomolov and Lang over finitely generated fields. Duke Math. J. 107 (2001), no. 1, 85-102.

Continuity of volumes on arithmetic varieties. J. of Algebraic geometry 18 (2009), 407-457.

Zariski decompositions on arithmetic surfaces, Publ. RIMS Kyoto Univ., 48 (2012), 799-898. (DOI) 10.2977/PRIMS/89.

Toward Dirichlet’s unit theorem on arithmetic varieties, Kyoto J. of Math., 53 (2013), 197-259. (DOI) 10.1215/21562261-1966116.

Semiample invertible sheaves with semipositive continuous hermitian metrics, Algebra and Number Theory, 9 (2015), 503-509.

■ Books

Arakelov geometry. Translations of Mathematical Monographs, vol 244, (2014), American Mathematical Society.

Adelic divisors on arithmetic varieties, Memoirs of the American Mathematical Society, Vol. 242, Num. 1144, DOI: http://dx.doi.org/10.1090/memo/1144, (2016).

K.Gotoh, M.Yamada and J.Mizushima, “The Theory of Stability of Spatially Periodic Parallel Flows”, J.Fluid Mech., Vol.127, 1983, pp.45-58.

M.Yamada, “Landau Equation and Mean Flow Distortion in Nonlinear Stability Theory of Parallel Free Flows”, J.Phys.Soc.Japan, Vol.55-8, 1986, pp.2641-2647.

M.Yamada and K.Ohkitani, “Lyapunov Spectrum of a Chaotic Model of Three Dimensional Turbulence”, J.Phys.Soc.Japan, Vol.56-12, 1987, pp.4210-4213.

K.Ohkitani and M.Yamada, “Temporal Intermittency in the Energy Cascade Process and Local Lyapunov Analysis in Fully-Developed Model Turbulence”, Prog.Theor.Phys., Vol.81-2, 1989, pp.329-341.

M.Yamada and K.Ohkitani, “An Identification of Energy Cascade in Turbulence by Orthonormal Wavelet Analysis”, Prog.Theor.Phys., Vol.86-4, 1991, pp.799-815.

S.Yoden and M.Yamada, “A Numerical Experiment on Two-Dimensional Decaying Turbulence on a Rotating Sphere”, J.Atmos.Sci., Vol.50-4, 1993, pp.631-643.

F.Sasaki and M.Yamada, “Biorthogonal Wavelet Adapted to Integral Operators and Their Applications”, Japan J. of Indust. Appl. Math., Vol.14, No.2, 1997, pp.257-277.

S.Kato and M.Yamada, “Unstable periodic solutions embedded in a shell model turbulence”, Phys.Rev.E., 68, 025302(R), 2003.

K.Ishimoto and M.Yamada, “A coordinate-based proof of the scallop theorem”, SIAM J. Appl. Math., 72(5), 1686-1694, 2012.

E.Sasaki, S.Takehiro and M.Yamada, 2015, “Bifurcation structure of two-dimensional viscous zonal flows on a rotating sphere”, Journal of Fluid Mechanics, 774, pp 224- 244, 2015.

Projective manifolds with ample tangent bundles, Ann. Math. 110(1979) 593–606.

Threefolds whose canonical bundles are not numerically effective, Ann. Math. 116 (1982) 133–176.

(with S. Mukai) Classification of Fano 3-folds with B2 ≥ 2, Manuscripta Math. 36 (1981) 147–162; Erratum 110 (2003) 407.

On 3-dimensional terminal singularities, Nagoya Math. J. 98 (1985) 43–66.

(with Y. Miyaoka) A numerical criterion of uniruledness, Ann. of Math. 124 (1986) 65–69.

Flip theorem and the existence of minimal models for 3-folds, Journal of the AMS 1 (1988) 117–253.

(with J. Koll ́ar and Y. Miyaoka) Rationally connected varieties, Journal of Alg. Geom. 1 (1992) 429–448.

(with S. Keel) Quotients by groupoids, Ann. of Math. 145 (1997) 193–213.

(with O. Fujino) A canonical bundle formula, J. Diff. Geom. 56(2000) 167–188.

(with Y. Prokhorov) On Q-conic bundles, Publ. Res. Inst. Math. Sci., 44 (2008) 315–369.

Shoko Suzuki, Dr. Phil., is Professor at Graduate School of Education, Kyoto University in Japan. Dr. Suzuki is also a member of the Science Council of Japan, the Board of Education in Kyoto and the Board of Directors of the Japanese Society for the Philosophy of Education. She was the academic leader of a program in Kyoto University’s Global Center of Excellence, titled “Revitalizing Education for Dynamic Hearts and Minds (2007-2012)”. Prior to that, Dr. Suzuki was involved in research activities at the University of Cologne, Germany from 1982 to 1989 and enjoyed a guest professorship at the Free University of Berlin, Germany from 2009 to 2010.

Suzuki, Shoko (2014): Ernährungspädagogik in Japan. In: Althans, B./Schmidt, F./Wulf, Chr.: Nahrung als Bildung. Interdisziplinäre Perspektiven auf einen anthropologischen Zusammenhang, Beltz Juventa; Weinheim/Basel 2014, S.128-138.

Suzuki, S./Wulf, Ch. (2013): Auf dem Weg des Lebens – West- östliche Meditation. Logos Verlag; Berlin.

Suzuki, S. (2013): Wisdom on the Pursuit of Happiness in Daily Life: Christmas Celebration in the German Family, Klien, S./Wulf, Chr. (Hrsg.) Paragrana- Internationale Zeitschrift für Historische Anthropologie, Band 22, Heft1: Well-Being – Emotions, Rituals, and Performances in Japan, P.235-248.

Suzuki, Shoko (2012):‚ The Kyoto School and J.F.Herbart‘. In: P. Standish,/N. Saito, (ed.): Education and the Kyoto School of Philosophy. Pedagogy for Human Transformation, Heidelberg/New York/London, P.41-53.

Suzuki, S./Wulf, Chr. u. anderen (2011): Glück der der Familie. Wiesbaden; VS Verlag für Sozialwissenschaften; Wiesbaden.

Suzuki, S. (2010):　Sein und Werden – Poiesis in Gesten, in: Wulf Chr./Fischer-Lichte, E. (Hrsg.): Geste, Wilhelm Fink, S. 116-122.

Suzuki, S. (2010): Takt in Modern Education. Münster/New York; Waxmann

Suzuki, S. (2008): Die Zukunft verhandeln. Aus der Sicht der Wissenschafts-kommunikation in der Risikoforschung und Bioethik Japans, in: Paragrana-Internationale Zeitschrift für Historische Anthropologie. Bd.17: Das Menschliche Leben, S.187-194.

Suzuki, S. (2008): Takt als Medium, in: Paragrana- Internationale Zeitschrift für Historische Anthropologie, Bd.16, S. 145-167.

Suzuki, S./Wulf, Chr. (ed.) (2007): Mimesis/Poiesis/Performativity. Münster/New York; Waxmann.